Human DLL4 Protein, Fc Tag

Source : 

Human DLL4, Fc Tag (DL4-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Pro 524 (Accession # NP_061947.1).

 

Molecule : DLL4

 

Synonyms : DLL4,Delta4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_061947.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 80.9 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.9 kDa. The protein migrates as 95-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4). DLL4 contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 plays a role in the Notch signaling pathway. DLL4 activates Notch-1 and Notch-4.

 

References :

(1) Zhang Z., et al., 2004, Protein Sci. 13:2819-2824.
(2) Brutsch R., et al., 2010, Circ. Res. 107:592-601.