Human DLL3 Protein, His Tag

Source : 

Human DLL3, His Tag (DL3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Leu 492 (Accession # Q9NYJ7-1).

 

Molecule : DLL3

 

Synonyms : Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_058637.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS with Arginine, pH7.4

 

Description :

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

 

References :

(1) Tanaka K., et al. 2018, Lung Cancer., 115, 116-120.
(2) Laura R. Saunders., et al. 2015, Sci Transl Med., 26, 7(302).
(3) Zhang J., et al. 2017, Oncol Lett., 13(6), 4533-4539.