Human DLL1 / Delta1 Protein, His Tag

Source : 

Human DLL1, His Tag (DL1-H52H8) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Gly 540 (Accession # NP_005609).

 

Molecule : DLL1

 

Synonyms : DLL1,Delta1,H-Delta-1

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_005609

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 58.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH 7.5

 

Description :

Delta-like protein 1 (DLL1) is also known as Drosophila Delta homolog 1 (Delta1 or H-Delta-1), which contains one DSL domain and eight EGF-like domains. DLL1 is ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. As for expression, DLL1 is expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Furthermore, DLL1 acts as a ligand for Notch receptors. Also, DLL1 can block the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

 

References :

(1) Han W., et al., 1999, Blood 95:1616-1625.
(2) Gray G.E., et al., 1998, Am. J. Pathol. 154:785-794
(3) Clark H.F., et al., 2002, Genome Res. 13:2265-2270.