Human Decorin Protein, His Tag

Source : 

Human Decorin, His Tag (DE1-H5223) is expressed from human 293 cells (HEK293). It contains AA Gly 17 - Lys 359 (Accession # NP_001911.1).

 

Molecule : Decorin

 

Synonyms : Decorin,DCN,CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001911.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.8 kDa. The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).

 

References :

(1) Santra, Manoranjan, et al., 2002, J. Biol. Chem. (United States) 277 (38): 35671–81.
(2) Iozzo, R V., et al., 1999, J. Biol. Chem. (UNITED STATES) 274 (8): 4489–92.
(3) Schönherr, E., et al., 1998, Arch. Biochem. Biophys. (UNITED STATES) 355 (2): 241–8.
(4) Takeuchi, Y., et al., 1994, J. Biol. Chem. (UNITED STATES) 269 (51): 32634–8.