Human DcR3 / TNFRSF6B Protein, Fc Tag

Source : 

Human DcR3, Fc Tag (TNB-H5255) is expressed from human 293 cells (HEK293). It contains AA Val 30 - His 300 (Accession # O95407-1).

 

Molecule : DcR3

 

Synonyms : TNFRSF6B,DCR3,TR6,M68

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH17065

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 56.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

 

References :

(1) Yu KY., et al., 1999, J Biol Chem 274 (20): 13733–6.
(2) Pitti RM., et al., 1999, Nature 396 (6712): 699–703.
(3) Zhang J., et al., 2001, J. Clin. Invest. 107 (11): 1459–68.