Human CTGF / CCN2 Protein, His Tag

Source : 

Human CTGF, His Tag (CTF-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # Q5M8T4-1).

 

Molecule : CTGF

 

Synonyms : CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_001892.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 37.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.4 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Potassium glutamate and Arginine, pH7.0

 

Description :

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

 

References :

(1) Faith Hall-Glenn., et al. 2011, Cell Mol Life Sci., 68(19), 3209–3217.
(2) Nakanishi T., et al. 2000, Endocrinology., 141(1), 264-73.
(3) Ball DK., et al. 2000, J Endocrinol., 176(2), R1-7.