Human Contactin-2 / Tag1 / CNTN2 Protein, His Tag

Source : 

Human Contactin-2, His Tag (CN2-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 31 - Asn 1012 (Accession # NP_005067.1).

 

Molecule : Contactin-2

 

Synonyms : CNTN2,AXT,DKFZp781D102,FLJ37193,FLJ42746,MGC157722,TAG-1,TAX,TAX1,Contactin-2

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_005067.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 108.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 108.3 kDa. The protein migrates as 116-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Contactin-2 is also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

 

References :

(1) Tsiotra PC, et al., 1993, Genomics 18 (3): 562–7. .
(2) Traka, M. et al., 2003, J. Cell. Biol. 162: 1161-1172.
(3) Mörtl M, ET AL., 2007, Protein Sci.16(10):2174-83.