Human CNTF R alpha Protein, His Tag

Source : 

Human CNTF R alpha, His Tag (CNR-H5225) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Pro 346 (Accession # AAH01492).

 

Molecule : CNTF R alpha

 

Synonyms : CNTFR,CNTF R alpha

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH01492

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 37.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.6 kDa. The protein migrates as 45-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Ciliary neurotrophic factor receptor subunit alpha (CNTFR or CNTFR-alpha) belongs to the type I cytokine receptor family and type 3 subfamily. CNTFR contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.

 

References :

(1) Davis S., et al., 1991, Science 253 (5015): 59–63.
(2) Sleeman MW., et al., 2000, Pharm Acta Helv 74 (2–3): 265–72.