Human CLEC12A / MICL / CLL-1 Protein, Fc Tag

Source : 

Human CLEC12A, Fc Tag (CLA-H5266) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

 

Molecule : CLEC12A

 

Synonyms : CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_612210.4

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 50.2 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

 

References :

(1) Toft-Petersen M, et al. 2016. Br J Haematol. 175(3):393-401.
(2) Neumann K, et al. 2014. Immunity. 40(3):389-99.
(3) Chen CH, et al. 2006. Blood. 107(4):1459-67.