Human CG alpha / CGA Protein, His Tag

Source : 

Human CG alpha, His Tag (CGA-H52H2) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Ser 116 (Accession # AAH20782).

 

Molecule : CG alpha

 

Synonyms : CGA,TSH-alpha,LSH-alpha,CG-alpha,FSH-alpha

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : AAH20782

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 12.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.1 kDa. The protein migrates as 22-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Chorionic gonadotrophin subunit alpha (CGA),a member of the glycoprotein hormones subunit alpha family, is also known as glycoprotein hormones alpha chain, choriogonadotropin alpha chain, follicle-stimulating hormone alpha chain (FSH-alpha), luteinizing hormone alpha chain (LSH-alpha) and thyroid-stimulating hormone alpha chain (TSH-alpha). The hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits (CGA) of these four human glycoprotein hormones are nearly identical, however, their beta chains are unique and confer biological specificity.

 

References :

(1) Sairam M.R., et al., 1977, Can. J. Biochem. 55:755-760.
(2) Rathnam P., et al., 1975, J. Biol. Chem. 250:6735-6746.
(3) Fan Q.R., et al., 2005, Nature 433:269-277.