Human CEACAM-1 / CD66a Protein, His Tag

Source : 

Human CEACAM-1, His Tag (CE1-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 35 - Gly 428 (Accession # AAH14473).

 

Molecule : CEACAM-1

 

Synonyms : CEACAM1,CD66a,BGP,BGP1,BGPI

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH14473

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 44.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.1 kDa. The protein migrates as 57-100 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is also known as Biliary glycoprotein 1 (BGP1), CD66a, which belongs to the immunoglobulin superfamily or CEA family. CEACAM1 /CD66a contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CEACAM1 /CD66a was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 / BGP-1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

 

References :

(1) Kuroki M., et al., 1991, Biochem. Biophys. Res. Commun. 176:578-585.
(2) Watt S.M., et al., 1994, Blood 84:200-210.
(3) Chen R., et al., 2009, J. Proteome Res. 8:651-661.
(4) Hoek KS., et al., 2008, Pigment Cell Melanoma Res. 21 (6): 665–76.