Human CD84 / SLAMF5 Protein, His Tag

Source : 

Human CD84, His Tag (CD4-H5229) is expressed from human 293 cells (HEK293). It contains AA Lys 22 - Gly 225 (Accession # AAH20063).

 

Molecule : CD84

 

Synonyms : CD84,SLAMF5,LY9B,SLAMF5

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH20063

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 23.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.6 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.

 

References :

(1) Martin M., et al., 2001, J. Immunol. 167:3668-3676.
(2) Tangye S.G., et al., 2002, Eur. J. Immunol. 32:1640-1649.
(3) Zaiss M., et al., 2003, Exp. Hematol. 31:798-805.