Human CD69 / CLEC2C Protein, His Tag

Source : 

Human CD69, His Tag (CD9-H5222) is expressed from human 293 cells (HEK293). It contains AA Ser 62 - Lys 199 (Accession # AAH07037).

 

Molecule : CD69

 

Synonyms : CD69,CLEC2C,AIM,BL-AC/P26,EA1,GP32/28,MLR-3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH07037

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 16.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.8 kDa. The protein migrates as 20-26 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Early activation antigen CD69 is also known as C-type lectin domain family 2 member C (CLEC2C), Activation inducer molecule (AIM), Early T-cell activation antigen p60, Leukocyte surface antigen Leu-23. CD69 contains one C-type lectin domain. CD69 / CLEC2C is expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. CD69 is induced by antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes and by interaction of IL-2 with the p75 IL-2R on the surface of NK cells. CD69 / CLEC2C involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

 

References :

(1) Natarajan K., et al., 2000, Biochemistry 39:14779-14786.
(2) Llera A.S., et al., 2001, J. Biol. Chem. 276:7312-7319.
(3) Vanek O., et al., 2008, FEBS J. 275:5589-5606.