Human CD6 / TP120 Protein, His Tag

Source : 

Human CD6, His Tag (CD6-H52H7) is expressed from human 293 cells (HEK293). It contains AA His 18 - Glu 398 (Accession # P30203-1).

 

Molecule : CD6

 

Synonyms : CD6,TP120,T12

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_006716.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.5 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. The majority of peripheral blood T cells, a subset of B cells, and a subset of neuronal cells express CD6. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and anti-CD2 mAb, support the concept of CD6 as a co stimulatory molecule.

 

References :

(1) Parnes JR et al., 1995, Eur J Immunol. 25: 2765.
(2) Bajorath J et al., 1997, Biochemistry 36: 2637.
(3) Fox DA et al., 1996, Immunology 88: 537.