Human CD58 / LFA-3 Protein, Fc Tag

Source : 

Human CD58, Fc Tag (LF3-H5256) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Arg 215 (Accession # AAH05930).

 

Molecule : CD58

 

Synonyms : CD58,LFA3,Ag3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH05930

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.1 kDa. As a result of differtent glycosylation, the protein migrates as 60-75 kDa under reducing (R) condition, and 125-150 kDa under non-reducing (NR) condi

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

 

References :

(1) Barbosa JA., et al., 1986, J. Immunol. 136 (8): 3085–91.
(2) Wang JH., et al., 1999, Cell 97 (6): 791–803.
(3) De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13): 5264–9.