Human CD46 Protein, His Tag

Source : 

Human CD46, His Tag (CD6-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 35 - Asp 328 (Accession # AAH30594.1).

 

Molecule : CD46

 

Synonyms : CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH30594.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 33.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

 

References :

(1) Lublin D.M., et al., 1988, J. Exp. Med. 168:181-194.
(2) Astier A., et al., 2000, J. Immunol. 164:6091-6095.
(3) Noris M., et al., 2003, Lancet 362:1542-1547.
(4) Kemper C., et al., 2003, Nature 421:388-392.