Human CD44 Protein, Fc Tag (HPLC-verified)

Source : 

Human CD44, Fc Tag (HPLC-verified) (PG1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 21 - Pro 220 (Accession # AAH04372).

 

Molecule : CD44

 

Synonyms : CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH04372

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.7 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

 

References :

(1) Goodison S., et al., 1999, MP, Mol. Pathol. 52 (4): 189–96.
(2) Hanley WD., et al., 2005, Cancer Res. 65 (13): 5812–7.
(3) Burdick MM., et al., 2006, J. Biol. Chem. 281 (20): 13899–905.
(4) Thomas SN., et al., 2008, J Biol Chem 283 (23): 15647–55.