Human CD40 / TNFRSF5 Protein, His Tag

Source : 

Human CD40, His Tag (CD0-H5228) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1).

 

Molecule : CD40

 

Synonyms : CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH12419.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 21.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.1 kDa. The protein migrates as 29-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).

 

References :

(1) Ferrari S., et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98:12614-12619,
(2) Singh J., et al., 1998, Protein Sci. 7:1124-1135.