Human CD300c / LMIR2 Protein, His Tag

Source : 

Human CD300c, His Tag (CDC-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Arg 183 (Accession # AAH22279).

 

Molecule : CD300c

 

Synonyms : CD300C,CLM-6,CMRF35-A1,CMRF-35,CMRF35A,IGSF16

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH22279

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.7 kDa. The protein migrates as 26-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.

 

References :

(1) Jackson D.G., et al., 1992, Eur. J. Immunol. 22:1157-1163.