Human CD30 / TNFRSF8 Protein, His Tag

Source : 

Human CD30, His Tag (CD0-H5229) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2).

 

Molecule : CD30

 

Synonyms : TNFRSF8,CD30,D1S166E,Ki-1

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_001234.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 39.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.3 kDa. The protein migrates as 48-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

 

References :

(1) Gorczyca W., et al., 2003, Int. J. Oncol. 22 (2): 319–24.
(2) Aizawa S., et al., 1997, J. Biol. Chem. 272 (4): 2042–5.
(3) Ansieau S., 1996, Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8.
(4) Lee S.Y., et al., 1996, J. Exp. Med. 183:669-674.