Human CD30 Ligand / TNFSF8 Protein, Mouse IgG2a Fc Tag, low endotoxin

Source : 

Human CD30 Ligand, Mouse IgG2a Fc Tag, low endotoxin (CDL-H525b) is expressed from human 293 cells (HEK293). It contains AA Gln 63 - Asp 234 (Accession # P32971-1).

 

Molecule : CD30 ligand

 

Synonyms : CD30-L,CD153,TNFSF8,CD30L,CD30LG,CD153 antigen,CD30 antigen ligand,CD30 Ligand

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_001235.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.5 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 46.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

CD30 ligand (CD30L) and CD30 are interacting cellsurface glycoproteins that are members of the tumour necrosis factor (TNF) and tumour necrosis factor receptor
(TNFR) superfamilies. In humans, CD30L is expressed at high levels on activated T cells. There is conflicting evidence with regard to cell surface expression of CD30L on primary human B cells. An initial report of constitutive CD30L expression on peripheral blood B cells33 has not been substantiated.

 

References :

(1) Marín ND., et al. 2017, Tuberculosis (Edinb)., 102, 8-15.
(2) Kennedy MK., et al. 2006, Immunology., 118(2), 143-52.
(3) Horie R., et al. 1998, Semin Immunol., 10(6), 457-70.