Human CD3 delta Protein, His Tag

Source : 

Human CD3 delta, His Tag (CDD-H5224) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # P04234-1).

 

Molecule : CD3 delta

 

Synonyms : CD3D,CD3-DELTA,T3D

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000723.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 11.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.4 kDa. The protein migrates as 18-28 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

 

References :

(1) Gil J, et al., 2011, J Clin Invest, 121(10):3872-6.
(2) Lu X, et al.,2011, Hematology, 16(3):185-9.
(3) Kim ST, et al., 2010, J Immunol, 185(5):2951-9.
(4) Holst, J. et al., 2008, Nat Immunol, 9 (6): 658-66.