Human CD27 / TNFRSF7 Protein, His Tag

Source : 

Human CD27, His Tag (CD7-H522b) is expressed from human 293 cells (HEK293). It contains AA Thr 21 - Ile 192 (Accession # P26842-1).

 

Molecule : CD27

 

Synonyms : CD27,TNFRSF7,S152,T14,Tp55

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_001233.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 21.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.1 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

 

References :

(1) Zhang Z., et al., 2004, Protein Sci. 13:2819-2824.
(2) Gravestein L.A., et al., 1998, Eur. J. Immunol. 28:2208-2216.
(3) Prasad K.V.S., et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351.