Human CD27 Ligand / CD70 Protein, His Tag

Source : 

Human CD27 Ligand, His Tag (CDL-H5246) is expressed from human 293 cells (HEK293). It contains AA Gln 39 - Pro 193 (Accession # P32970-1).

 

Molecule : CD27 Ligand

 

Synonyms : CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_001243.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 19.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 19.0 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

 

References :

(1) McEarchern JA. et al., 2008, Clin Cancer Res., 14(23):7763-72.
(2) Croft M., 2003, Nat Rev Immunol., 3(8):609-20.
(3) Kobata, TS. et al., 1995, Proc. Natl. Acad. Sci. USA, 92: 11249–11253.
(4) Raman V.S. et al., 2003, J Immunol., 171(11):5876-81.
(5) Takeda, K. et al., 2000, J Immunol., 15;164(4):1741-5.