Human CD24 Protein, Fc Tag

Source : 

Human CD24, Fc Tag (CD4-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Gly 59 (Accession # P25063-1).

 

Molecule : CD24

 

Synonyms : CD24,CD24A

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001278666.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 29.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 29.6 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

 

References :

(1) Suzuki T1, et al. 2001. J Immunol. 166(9):5567-77.
(2) Chen Z, et al. 2017. Biomed Pharmacother. 90:427-436.
(3) Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18(4):328-336.