Human CD206 / MMR Protein, His Tag

Source : 

Human CD206, His Tag (CD6-H52H9) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Ala 1389 (Accession # P22897-1).

 

Molecule : CD206

 

Synonyms : MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002429.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 158.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 158.6 kDa. The protein migrates as 150-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

 

References :

(1) Scodeller P, et al. 2017. Sci Rep. 7(1):14655.
(2) Masai H, et al. 2017. Curr Genet. 63(5):813-818.
(3) Matsumoto S, et al. 2017. Mol Cell Biol. 37(7). pii: e00355-16.