Human CD200 / OX-2 Protein, Fc Tag

Source : 

Human CD200, Fc Tag (OX2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # AAH22522).

 

Molecule : CD200

 

Synonyms : CD200,MOX1,MOX2,MRC,OX-2,My033

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH22522

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.6 kDa. The protein migrates as 55-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

 

References :

(1) McCaughan, G.W. et al., 1987, Immunogenetics 25:329-335.
(2) Chen, Z. et al., 2006, Mol Immunol. 43 (6): 579-587.
(3) Wright GJ., et al., 2003, J. Immunol. 171 (6): 3034–46.