Human CD163 Protein, His Tag

Source : 

Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7).

 

Molecule : CD163

 

Synonyms : CD163,M130

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : Q86VB7

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 110.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 110.4 kDa. The protein migrates as 135-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is also known as hemoglobin scavenger receptor, which is a scavenger receptor for the hemoglobin-haptoglobin complex. CD163 has also been shown to mark cells of monocyte/macrophage lineage. A soluble form of the receptor exists in plasma, commonly denoted sCD163. sCD163 is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.

 

References :

(1) Law S.K.A., et al., 1993, Eur. J. Immunol. 23:2320-2325.
(2) Matsushita N., et al., 2002, Clin. Exp. Immunol. 130:156-161.
(3) Ritter M., et al., 2001, Eur. J. Immunol. 31:999-1009.