Human CD160 Protein, His Tag

Source : 

Human CD160, His Tag (BY5-H5229) is expressed from human 293 cells (HEK293). It contains AA Ile 27 - Ser 159 (Accession # O95971-1).

 

Molecule : CD160

 

Synonyms : CD160,BY55,NK1,NK28

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_008984.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 16.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.7 kDa. The protein migrates as 25-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD160 antigen is also known as natural killer cell receptor BY55, is a 27 kDa glycoprotein, contains 1 Ig-like V-type (immunoglobulin-like) domain. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. When expressed on vascular endothelial cells, CD160 propagates anti-angiogenic signals and promotes apoptosis.

 

References :

(1) Anumanthan A., et al., 1998, J. Immunol. 161:2780-2790.
(2) Agrawal S., et al., 1999, J. Immunol. 162:1223-1226.