Human CD155 / PVR Protein, Mouse IgG2a Fc Tag, low endotoxin

Source : 

Human CD155, Mouse IgG2a Fc Tag, low endotoxin (CD5-H5254) is expressed from human 293 cells (HEK293). It contains AA Trp 21 - Asn 343 (Accession # NP_006496.4).

 

Molecule : CD155

 

Synonyms : PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_006496.4

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.2 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 62.2 kDa. As a result of glycosylation, the protein migrates as 70-100 kDa under reducing (R) condition, and 130-160 kDa under non-reducing (NR) condition (SDS

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that is encoded by the PVR gene. CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.

 

References :

(1)Zhang P., et al., 2008, Proc. Natl. Acad. Sci., 105 (47): 18284-18289.
(2Maier MK., et al., 2007, European Journal of Immunology, 37 (8): 2214-2225.
(3)He Y., et al., 2000, Proc. Natl. Acad. Sci., 97 (1): 79-84.