Human Cathepsin S / CTSS Protein, His Tag

Source : 

Human Cathepsin S, His Tag (CTS-H5224) is expressed from human 293 cells (HEK293). It contains AA Gln 17 - Ile 331 (Accession # P25774-1).

 

Molecule : Cathepsin S

 

Synonyms : CTSS,Cathepsin S

 

Format : Powder

 

Category : Enzymes

 

Accession : NP_004070.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 24.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 36-42 kDa (pro) and 26 kDa (mature) under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM MES, 100 mM NaCl, pH6.5

 

Description :

Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

 

References :

(1) Burkard T.R., et al., 2011, BMC Syst. Biol. 5:17-17.