Human CADM1 / IGSF4A Protein, His Tag

Source : 

Human CADM1, His Tag (CA1-H5225) is expressed from human 293 cells (HEK293). It contains AA Gln 45 - His 374 (Accession # NP_055148.3).

 

Molecule : CADM1

 

Synonyms : CADM1,BL2,IGSF4,IGSF-4,IGSF4A,NECL2,Necl-2,RA175,ST17,SYNCAM,TSLC1,sTSLC-1,sgIGSF,synCAM1,DKFZp686F1789,MGC149785,MGC51880

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_055148.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 37.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.9 kDa. The protein migrates as 50 kDa and 55-85 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. Cell adhesion molecule 1 is a single-pass type I membrane protein which belongs to the nectin family. Cell Adhesion Molecule 1 contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain, and is also known as CADM1; BL2; DKFZp686F1789; IGSF4; IGSF4A; MGC149785; MGC51880; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1. CADM1 mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. CADM1 may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

 

References :

(1) Kuramochi M. 2001, Nat. Genet. 27: 427-430 .
(2) Yageta M. et al., 2002, Cancer Res. 62: 5129-5133.
(3) Furuno T. et al., 2005, J. Immunol. 174: 6934-6942.
(4) Boles KS. et al., 2005, Blood. 106: 779-786.
(5) Dong X. et al., 2006  J. Biol. Chem. 281: 10610-7.