Human Cadherin-6 / KCAD / CDH6 Protein, His Tag

Source : 

Human Cadherin-6, His Tag (CA6-H5229) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Ala 615 (Accession # AAH00019).

 

Molecule : Cadherin-6

 

Synonyms : CDH6,CAD6,KCAD,K-cadherin,Cadherin-6

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH00019

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 67.2 kDa & 63.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus.
The Human Cadherin-6 will be further processed into mature form (Ser 54-Ala 615). The protein has a calculated MW of 67.2 kDa (pro-form) and 63.4 kDa (mature-form). The protein migrates as 86-96

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

 

References :

(1) Suzuki S., et al., 1991, Cell Regul. 2:261-270.
(2) MacCalman CD., et al., 1998, Am. J. Reprod. Immunol. 39 (2): 96–107.