Human C1q R1 / CD93 Protein, His Tag

Source : 

Human C1q R1, His Tag (C11-H5228) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Lys 580 (Accession # AAH28075).

 

Molecule : C1q R1

 

Synonyms : CD93,CDw93,C1QR1,MXRA4,C1qR,C1qR(P),C1qRP,ECSM3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH28075

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 59.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.2 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

CD antigen CD93 is also known as Complement component C1q receptor (C1QR1). which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.

 

References :

(1) Ghebrehiwet B., et al., 1997, J. Immunol. 159:1429-1436.
(2) Nepomuceno R.R., et al., 1999, J. Immunol. 162:3583-3589.
(3) Kittlesen D.J., et al., 2000, J. Clin. Invest. 106:1239-1249.