Human BTN3A3 / BTF3 Protein, His Tag

Source : 

Human BTN3A3, His Tag (BT3-H52H0) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Trp 248 (Accession # AAH15815).

 

Molecule : BTN3A3

 

Synonyms : BTN3A3,BTF3

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH15815

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 25.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.5 kDa. The protein migrates as 28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Butyrophilin subfamily 3 member A3 (BTN3A3),a member of the immunoglobulin superfamily and BTN/MOG family, is also known as BTF3, which contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A3 is detected in peripheral blood mononuclear cells ,T-cells ,spleen and lymphocytes. BTN3A3 also plays a role in T-cell responses in the adaptive immune response. Stimulation of human butyrophilin 3(BTN3) molecules results in negative regulation of cellular immunity.

 

References :

(1) Yamashiro H., et al., 2010, J. Leukoc. Biol. 88:757-767.
(2) Palakodeti A., et al., 2012, J. Biol. Chem. 287:32780-32790.