Human BTN3A1 / CD277 Protein, Fc Tag

Source : 

Human BTN3A1, Fc Tag (BT1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Gly 254 (Accession # AAI21801).

 

Molecule : BTN3A1

 

Synonyms : BTN3A1,CD277,BTF5

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAI21801

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.8 kDa. As a result of glycosylation, the protein migrates as 58-65 kDa under reducing (R) condition, and 120 kDa under non-reducing (NR) condition (SDS-PAGE)

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Butyrophilin subfamily 3 member A1 (BTN3A1) is also known as CD277 and BTF5, which belongs to the immunoglobulin superfamily and contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A1 plays a role in T-cell activation and in the adaptive immune response. Also, BTN3A1 regulates the proliferation of activated T-cells and the release of cytokines and IFNG by activated T-cells. Furthermore, BTN3A1 mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

 

References :

(1) Yamashiro H., et al., 2010, J. Leukoc. Biol. 88:757-767.
(2) Messal N., et al., 2011, Eur. J. Immunol. 41:3443-3454.
(3) Harly C., et al., 2012, Blood 120:2269-2279.