Human BTN1A1 / Butyrophilin Protein, Fc Tag

Source : 

Human BTN1A1, Fc Tag (BT1-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 242 (Accession # AAH96312).

 

Molecule : BTN1A1

 

Synonyms : BTN1A1,Butyrophilin,BTN

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH96312

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.6 kDa. As a result of glycosylation, the protein migrates as 55-66 kDa under reducing (R) condition, and 116-130 kDa under non-reducing (NR) condition (SDS-P

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Butyrophilin subfamily 1 member A1 (BTN1A1) is also known as BTN, which is a member of the immunoglobulin superfamily and the major protein associated with fat droplets in the milk. BTN1A1 may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families. Furthermore, BTN1A1 regulates the amount of lipids and size of droplets expressed in milk and inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

 

References :

(1) Taylor M.R., et al., 1996, Biochim. Biophys. Acta 1306:1-4.
(2) Mather IH., et al., 1993, J. Dairy Sci. 76 (12): 3832–50.