Human BTLA (31-150) Protein, Fc Tag

Source : 

Human BTLA, Fc Tag (BTA-H5256) is expressed from human 293 cells (HEK293). It contains AA Lys 31 - Ser 150 (Accession # AAP44003.1).

 

Molecule : BTLA

 

Synonyms : BTLA,CD272

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAP44003.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 40.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 46-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

 

References :

(1) Watanabe N., et al., 2003, Nat. Immunol. 4:670-679.
(2) Gavrieli M., et al., 2003, Biochem. Biophys. Res. Commun. 312:1236-1243.
(3) Sedy J.R., et al., 2005, Nat. Immunol. 6:90-98.