Human BMPR-IA / ALK-3 Protein, Fc Tag

Source : 

Human BMPR-IA, Fc Tag (AL3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # P36894-1).

 

Molecule : BMPR-IA

 

Synonyms : BMPR-1A,ALK-3,10q23del,ACVRLK3,CD292,SKR5

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : CAA80257

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 40.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.3 kDa. The protein migrates as 56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2[1]. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

 

References :

(1) Mishina Y, Starbuck MW , et al.,2004, J. Biol. Chem. 279 (26): 27560–6.
(2) Song L, Fässler R, et al., 2007, Dev Biol. 301(1):276-86.