Human BMP-2 Protein, Tag Free

Source : 

Human BMP-2, Tag Free (BM2-H4117) is expressed from E.coli cells. It contains AA Ala 284 - Arg 396 (Accession # NP_001191).

 

Molecule : BMP-2

 

Synonyms : BMP2,BMP2A

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_001191

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 12.8 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. the protein migrates as 14 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 100 mM Acetic Acid, pH2.8

 

Description :

Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.

 

References :

(1) Lai, T.H. et al., (2008) Prostate. 68: 1341-1353.
(2) Kruithof BP,et al. Genesis. 2011 Apr 18. doi: 10.1002/dvg.20757.
(3) Grgurevic L, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):25-31.