Human BCMA / TNFRSF17 Protein,His Tag

Source : 

Human BCMA, His Tag (BCA-H522y) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # Q02223-1).

 

Molecule : BCMA

 

Synonyms : TNFRSF17,CD269,BCM,BCMA

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001183.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 7.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 7.8 kDa. The protein migrates as 12 kDa and 15-17 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

 

References :

(1) Hatzoglou A., et al., 2000, J. Immunol. 165:1322-1330.
(2) Gross J.A., et al., 2000, Nature 404:995-999.
(3) Yu G., et al., 2000, Nat. Immunol. 1:252-256.