Human Bcl-x / BCL2L1 Protein, His Tag

Source : 

Human Bcl-x, His Tag (BC1-H5120) is expressed from E.coli cells. It contains AA Met 1 - Arg 212 (Accession # AAH19307).

 

Molecule : Bcl-x

 

Synonyms : BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL/S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH19307

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 24.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.6 kDa. The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 20 mM HEPES, 50 mM KCl, pH7.5

 

Description :

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

 

References :

(1) Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
(2) Wang J., et al., 2011, Cell. Signal. 23:2030-2038.