Human BAFFR / TNFRSF13C Protein, Fc Tag

Source : 

Human BAFFR, Fc Tag (BAR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ser 7 - Ala 71 (Accession # Q96RJ3-1).

 

Molecule : BAFFR

 

Synonyms : BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_443177.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 33.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

 

References :

(1)Thompson JS., et al.,2001, Science, 293 (5537): 2108-2111.
(2)Mbrose CM., 2003, Journal of Biological Regulators and Homeostatic Agents, 16 (3): 211-213.
(3)Treml LS., et al., 2006, Seminars in Immunology, 18 (5): 297-304.