Human B7-H7 / HHLA2 Protein, His Tag

Source : 

Human B7-H7, His Tag (B77-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Asn 344 (Accession # Q9UM44-1).

 

Molecule : B7-H7

 

Synonyms : B7-H7,HHLA2,B7 Homolog 7

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_009003.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.9 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.

 

References :

(1) Ni L., et al., 2017, Mol. Cancer. Ther. 16:1203-1211.
(2) Jung K., et al., 2013, Immune. Netw. 13:184-193.
(3) Janakiram M., et al., 2015, Clin. Cancer. Res. 21:2359-2366.