Human B7-H5 / Gi24 / VISTA Protein, Fc Tag

Source : 

Human B7-H5, Fc Tag (B75-H5259) is expressed from human 293 cells (HEK293). It contains AA Phe 33 - Ala 194 (Accession # AAH20568).

 

Molecule : B7-H5

 

Synonyms : B7-H5,SISP1,Gi24,VISTA

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH20568

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 44.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

 

References :

(1) Sakr M.A., et al., 2010, Cancer Sci. 101:2368-2374.
(2) Mayya V., et al ., 2009, Sci. Signal. 2:RA46-RA46.