Human B7-H4 Protein, His Tag

Source : 

Human B7-H4, His Tag (B74-H5222) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # NP_078902).

 

Molecule : B7-H4

 

Synonyms : B7-H4,VTCN1,B7S1,B7h.5

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_078902

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 26.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.4 kDa. The protein migrates as 43-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

 

References :

(1) Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
(2) Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
(3) Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.