Human Azurocidin / CAP37 / AZU1 Protein, His Tag

Source : 

Human Azurocidin, His Tag (AZ1-H5225) is expressed from human 293 cells (HEK293). It contains AA Ile 27 - Pro 250 (Accession # AAH69495).

 

Molecule : Azurocidin

 

Synonyms : AZU1,Azurocidin,HBP,AZAMP,AZU,CAP37,HUMAZUR,NAZC

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH69495

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 25.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.0 kDa. The protein migrates as 34-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.

 

References :

(1) Wasiluk K.R., et al., 1991, Infect. Immun. 59:4193-4200.
(2) Miyasaki K.T., 1992, Infect. Immun. 60:4973-4975.
(3) Linder A., 2009, Clin. Infect. Dis. 49 (7): 1044–50.