Human Axl Protein, His Tag

Source : 

Human Axl, His Tag (AXL-H5226) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Pro 449 (Accession # AAH32229).

 

Molecule : Axl

 

Synonyms : AXL,UFO

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH32229

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 46.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

 

References :

(1) Varnum B.C., et al., 1995, Nature 373:623-626.
(2) Gallicchio M., et al., 2005, Blood 105:1970-1976.
(3) Park I.K., et al., 2009, Blood 113:2470-2477.