Human APRIL / TNFSF13 Protein, His,Flag Tag, active trimer (MALS verified)

Source : 

Human APRIL, His,Flag Tag, active trimer (APL-H52D1) is expressed from human 293 cells (HEK293). It contains AA Gln 111 - Leu 250 (Accession # O75888-1) trimer Design.

 

Molecule : APRIL

 

Synonyms : APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_003799.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The protein has a calculated MW of 50.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.

 

References :

(1) García-Castro A, et al. 2015, Carcinogenesis., 36(5):574-84.
(2) Schuepbach-Mallepell S, et al. 2015, J Biol Chem., 290(26):16330-42.
(3) Zhi X, et al. 2015, Cell Physiol Biochem, 35(2):571-85.