Human APCS / SAP / PTX2 Protein, His Tag

Source : 

Human APCS, His Tag (APS-H5229) is expressed from human 293 cells (HEK293). It contains AA His 20 - Val 223 (Accession # P02743-1).

 

Molecule : APCS

 

Synonyms : PTX2,APCS,SAMP,SAP,Pentraxin 2

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001630.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 24.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.1 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH 7.5

 

Description :

Serum amyloid P-component (SAP) is also known as Pentraxin 2 (PTX2), APCS, which belongs to the pentaxin family. SAP contains one pentaxin domain. PTX2 is a secreted homopentamer protein which is found in serum and urine. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. SAP may also function as a calcium-dependent lectin. SAP has certain sequence homology with C-reactive protein (CRP).

 

References :

(1) Prelli F., et al., 1985, J. Biol. Chem. 260:12895-12898.
(2) Pepys M.B., et al., 1994, Proc. Natl. Acad. Sci. U.S.A. 91:5602-5606.
(3) Kiernan U.A., et al., 2004, Proteomics 4:1825-1829.